Treatment Response Evaluation by Computed Tomography Pulmonary Vasculature Analysis in Patients With Chronic Thromboembolic Pulmonary Hypertension

Yu-Sen Huang, Zheng-Wei Chen, Wen-Jeng Lee, Cho-Kai Wu, Ping-Hung Kuo, Hsao-Hsun Hsu, Shu-Yu Tang, Cheng-Hsuan Tsai, Mao-Yuan Su, Chi-Lun Ko, Juey-Jen Hwang, Yen-Hung Lin, Yeun-Chung Chang
Korean Journal of Radiology
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In this study, researchers evaluated the pulmonary vasculature of 30 chronic thromboembolic pulmonary hypertension (CTEPH) patients using non-contrast computed tomography (CT) before and after treatment. They correlated CT-based parameters with right heart catheterization (RHC) hemodynamic and clinical parameters. Leveraging the Aview system (Coreline Soft, Inc.) for lung segmentation and pulmonary vasculature analysis, the researchers found significant increases in the number, area, and density of subpleural small vessels post-treatment. Additionally, blood volume shifted from larger to smaller vessels, and the BV5/TBV ratio correlated with hemodynamic and clinical parameters. The study highlights the effectiveness of non-contrast CT measures, aided by the Aview software, in evaluating changes in pulmonary vasculature in response to treatment.